Epoxyquinol A, a Highly Functionalized Pentaketide Dimer with Antiangiogenic Activity Isolated from Fungal Metabolites
- 15 March 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (14) , 3496-3497
- https://doi.org/10.1021/ja0127279
Abstract
A unique pentaketide dimer structure of a novel fungal metabolite with antiangiogenic activity, designated as epoxyquinol A (1), was determined on the basis of NMR spectral data as well as the X-ray crystallographic analysis. 1 inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 3 μg/mL).Keywords
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