The Flourishing Syntheses of Non-Nucleoside Reverse Transcriptase Inhibitors
- 31 December 2000
- journal article
- review article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2000 (04) , 479-495
- https://doi.org/10.1055/s-2000-6357
Abstract
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of increasing importance in the treatment of HIV-1 infected persons. In this review the focus is on the syntheses of the approved NNRTI drugs efavirenz, delavirdine, nevirapine, and their analogues. This review also deals with the syntheses of the most promising NNRTI candidates in clinical testing and with the syntheses of subclasses of NNRTIs with known crystal structures when complexed with the reverse transcriptase enzyme.Keywords
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