EFFECT OF ACETYLCHOLINE ON GLYCOGEN-PHOSPHORYLASE ACTIVITY AND CYCLIC NUCLEOTIDE CONTENT IN ISOLATED PERFUSED RAT HEARTS
- 1 January 1976
- journal article
- research article
- Vol. 2 (3) , 171-178
Abstract
Acetylcholine (1 .mu.M) increased cyclic GMP content in paced perfused rat hearts within 15 s, with peak content occurring at 1 min. No effect of acetylcholine on cyclic AMP content, phosphorylase activity or glycogen synthase was observed. Epinephrine (1 .mu.M) infusion increased both cyclic AMP content and phosphorylase but did not alter cyclic GMP content or glycogen synthase activity. When acetylcholine was infused during the 2nd min of a 2 min infusion of epinephrine, the cholinergic agent increased cyclic GMP and reduced the stimulated phosphorylase activity and elevated cyclic AMP.This publication has 6 references indexed in Scilit:
- KINETIC STUDIES OF EPINEPHRINE EFFECTS IN PERFUSED RAT HEART1966
- ELECTROLYTE CONTENT OF PERFUSED RAT VENTRICLES EXPOSED TO HALOTHANE OR ANOXIA1966
- EFFECT OF EPINEPHRINE ON ADENOSINE 3',5'-PHOSPHATE LEVELS IN ISOLATED PERFUSED RAT HEART1965
- INHIBITORY EFFECT OF ACETYLCHOLINE ON GLYCOGENOLYSIS IN ISOLATED GUINEA-PIG HEART1963
- ROLE OF AUTONOMIC NERVOUS SYSTEM IN REGULATION OF HEART PHOSPHORYLASE IN OPEN-CHEST RAT1962
- ADENYL CYCLASE .3. EFFECT OF CATECHOLAMINES AND CHOLINE ESTERS ON FORMATION OF ADENOSINE 3'85'-PHOSPHATE BY PREPARATIONS FROM CARDIAC MUSCLE AND LIVER1962