Mobilized Blood Stem Cells: Immunophenotyping and Functional Characteristics
- 1 January 1992
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Hematotherapy
- Vol. 1 (1) , 19-26
- https://doi.org/10.1089/scd.1.1992.1.19
Abstract
High levels of peripheral blood stem cells (PBSC) can be collected from patients with hematopoietic malignancies or solid tumors after high-dose chemotherapy and/or growth factors. Rapid, complete, and durable hematopoietic reconstitution has been observed in patients who have been transplanted with PBSC after conditioning with supralethal myeloablative therapy. We will review the recent data concerning the immunophenotype and functional capacities of mobilized blood stem cells. PBSC seem to be comprised of a mixture of primitive and committed hematopoietic progenitors and are not that different from bone marrow-derived stem cells.Keywords
This publication has 27 references indexed in Scilit:
- Peripheral blood The International Journal of Cell Cloning contain pluripotent cellsThe International Journal of Cell Cloning, 1992
- Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma.The Journal of Experimental Medicine, 1990
- Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro.Journal of Clinical Investigation, 1988
- Cell surface antigens on human marrow cells: Dissection of hematopoietic development using monoclonal antibodies and multiparameter flow cytometryThe International Journal of Cell Cloning, 1987
- High levels of circulating haemopoietic stem cells in very early remission from acute non‐lymphoblastic leukaemia and their collection and cryopreservationBritish Journal of Haematology, 1984
- Studies of hematopoietic stem cells spared by 5-fluorouracil.The Journal of Experimental Medicine, 1984
- Transfusion of Circulating Stem CellsCRC Critical Reviews in Clinical Laboratory Sciences, 1984
- CFU‐C Populations in Blood and Bone Marrow of Dogs after Lethal Irradiation and Allogeneic Transfusion with Cryopreserved Blood Mononuclear CellsScandinavian Journal of Haematology, 1978
- Conditions controlling the proliferation of haemopoietic stem cells in vitroJournal of Cellular Physiology, 1977
- Limited potential of circulating haemopoietic stem cellsNature, 1975