Human leucocyte antigen (HLA) and malaria morbidity in a Gambian community
- 1 May 1993
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 87 (3) , 286-287
- https://doi.org/10.1016/0035-9203(93)90130-i
Abstract
Human leucocyte antigen (HLA) class I and class II typing was performed on 177 children in a rural area of The Gambia who were followed for 2 years in a longitudinal study of malaria morbidity. A comparison was made between those who experienced an episode of clinical malaria in one or both years and those who showed no evidence of infection in either year. No convincing association was found between morbidity and class I phenotype. An overall association of morbidity with the distribution of class II haplotypes was seen, but associations with individual DR-DQ haplotypes were not conclusive.Keywords
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