Thiabendazole Probable Cure for Trichinosis

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Abstract
THIABENDAZOLE ( 2-( 4′thiazolyl) -benzimidazole) represents a new class of broad spectrum anthelmintics with a wide range of activity.1 In addition to its marked potency against helminths, it has negligible mammalian toxicity. This drug has been the subject of intense veterinary research.2-7 It is limited to investigational use in humans, but is currently being evaluated in this country and several foreign areas. Studies from Brazil8 and Liberia9 indicate that it is highly effective in cases of human strongyloidiasis. There were no serious side effects in the total 140 cases reported. In a small number of patients treated, transient dizziness, drowsiness, nausea, or vomiting occurred. One child receiving over 2 1/2 times the normal dosage developed a papular eruption. Some of these minor side effects might be the result of the release of toxic material derived from dead parasites. The authors10 recently reported the first systemic use