Effect of hydrocortisone on pancreatic growth in rats

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Abstract
Effects of hydrocortisone on pancreatic size and composition was studied in suckling, recently weaned, growing and adult rats. The data demonstrate that hydrocortisone is associated with hyperplasia and hypertrophy of the pancreas in suckling rats, suppressed DNA synthesis in recently weaned rats, but maintained the hypertrophic effect, increased protein and pancreatic hydrolase concentrations in growing and adult rats and preferentially promoted synthesis of amylase over chymotrypsin only during the suckling period. Apparently pancreas growth may be partly under control of glucocorticoids only during the suckling period; hypertrophy of the pancreatic tissue can be obtained at all ages by these hormones.