PERSISTENT SHEDDING OF WEST NILE VIRUS IN URINE OF EXPERIMENTALLY INFECTED HAMSTERS
- 1 March 2005
- journal article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 72 (3) , 320-324
- https://doi.org/10.4269/ajtmh.2005.72.320
Abstract
Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidemiologic importance are discussed.Keywords
This publication has 1 reference indexed in Scilit:
- West Nile Virus: Epidemiology and Ecology in North AmericaPublished by Elsevier ,2003