The Effects of Polypodium leucotomos Extract on the Specific Antibody Production Patterns in BALB/c Mice Immunized with Third Stage Larvae Antigens of Anisakis simplex

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Abstract
The immunomodulant effects of Polypodium leucotomos extracts have been tested in BALB/c mice immunized with the third larval stage antigens of Anisakis simplex. A decrease in the specific antibodies was observed in animals treated either before or after immunization. This decrease was mainly in the IgG 1 isotype. In animals treated before immunization the reduction of the IgG 1 subclass was dramatic in relation to the untreated group while the IgG 2b subclass appeared earlier and at slightly higher levels than in the control group. In animals treated after immunization a reduction of the IgG 1 subclass was also observed although not as marked as in the preimmunization group. IgG 2a sub-class antibody levels were higher than those of the untreated group. As in the preimmunization group, the IgG 2b subclass antibodies appeared earlier but they remained at similar levels to those observed in the control group.