Production of parathyroid hormone‐related protein by cultured human myeloma cells
- 1 January 1994
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 45 (1) , 88-90
- https://doi.org/10.1002/ajh.2830450115
Abstract
We examined whether or not parathyroid hormone‐related protein (PTH‐rP) is produced in cultured human myeloma cells. PTH‐rP protein was detected in the cell extract of one (U266) of 6 myeloma cell lines examined by radioimmunoassay. Also we demonstrated the expression of PTH‐rP mRNA in all of the 6 lines. These findings indicate that PTH‐rP may be one of the factors responsible for the bone destruction or hypercalcemia in multiple myeloma.Keywords
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