Advanced model predictive control (MPC) for type I diabetic patient blood glucose control
- 1 January 2000
- conference paper
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- Vol. 35 (07431619) , 3483-3487 vol.5
- https://doi.org/10.1109/acc.2000.879216
Abstract
Advanced control strategies for delivering insulin to type I diabetic patients are developed. Utilizing the model predictive control (MPC) framework, an asymmetric objective function is tailored to address the inherent performance requirements of the physiological problem. This technique is then compared to an MPC controller incorporating prioritized objectives. In an in-patient setting, a second manipulated variable (glucose infusion) could be made available. This multiple-input single-output (MISO) problem is reformulated as a multiple-input multiple-output (MIMO) output regulator problem and is solved using the above techniques. Performance in all cases was demonstrably superior to previous results based on standard MPC formulations using symmetric objective functions.Keywords
This publication has 9 references indexed in Scilit:
- Propositional logic in control and monitoring problemsAutomatica, 1999
- A model-based algorithm for blood glucose control in Type I diabetic patientsIEEE Transactions on Biomedical Engineering, 1999
- Simulation studies on neural predictive control of glucose using the subcutaneous routeComputer Methods and Programs in Biomedicine, 1998
- Advances Toward the Implantable Artificial Pancreas for Treatment of DiabetesDiabetes Care, 1998
- The Absence of a Glycemic Threshold for the Development of Long-Term Complications: The Perspective of the Diabetes Control and Complications TrialDiabetes, 1996
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1993
- Output Constraint Softening for SISO Model Predictive ControlPublished by Institute of Electrical and Electronics Engineers (IEEE) ,1993
- Recent Developments in Insulin Delivery TechniquesDrugs, 1991
- Does Physiological Blood Glucose Control Require an Adaptive Control Strategy?IEEE Transactions on Biomedical Engineering, 1987