INHIBITION OF CFU-S ENTRY INTO CELL-CYCLE AFTER IRRADIATION AND DRUG-TREATMENT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 29  (5) , 176-178
Abstract
The cell cycle inhibition of [mouse] pluripotent bone marrow stem cells (CFU-S) by a fetal calf bone marrow extract (BME) was studied. The normally quiescent cells were made to enter the cell cycle by treatment with irradiation or the phase specific drug cytosine arabinoside (Ara-C). Using the vitro-vivo system of Frindel et al., when the BME was added to the incubation medium, no triggering of CFU-S into cycle could be observed. The inhibitory effect was also demonstrated when the BME was injected simultaneously with the drug. The possible relationships of BME with stimulating factors controlling CFU-S entry into cycle are discussed. [The prevention of the entry of CFU-S into the cell cycle during chemotherapy, without producing such as effect on tumor cells, was discussed.].