High-Affinity Anti-DNA Antibody Parallels Clinical Course of Immunoadsorption Therapy for Systemic Lupus Erythematosus.
- 1 January 1996
- journal article
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 35 (5) , 367-372
- https://doi.org/10.2169/internalmedicine.35.367
Abstract
Anti-DNA antibody, especially high-affinity anti-DNA antibody (ADNA), is thought to have an important role in the pathogenesis of lupus nephritis. In this study, ADNA which binds to double-stranded DNA under a high concentration of sodium chloride was measured in patients who had received immunoadsorption (IA) therapy with a dextran-sulfate column. Titers of high-affinity ADNA in the cases with renal dysfunction tended to be higher than in those without renal dysfunction. The change in the titer of high-affinity ADNA paralleled the clinical course. These findings suggest that measurement of high-affinity ADNA is useful for follow-up of the clinical course of patients who have undergone IA therapy.Keywords
This publication has 0 references indexed in Scilit: