Establishment and characterization of a murine hybridoma secreting monoclonal anti-DNA autoantibody.

Open Access

1 December 1980

journal article
research article
Published by Oxford University Press (OUP) in The Journal of Immunology

Vol. 125 (6) , 2805-2809
https://doi.org/10.4049/jimmunol.125.6.2805

Abstract

Twenty-five clones of hybridoma cells secreting anti-DNA autoantibodies were isolated after fusions between plasmacytoma cells (P3-x 63 Ag 8.653) and spleen cells from nonimmunized autoimmune NZB/NZW F1 (B/W) mice. A monoclonal anti-DNA autoantibody was immunochemically analyzed.