Further Studies in Genetic Resistance of Fowl to RSV(RAV 0): Evidence for Interaction between Independently Segregating Tumour Virus b and Tumour Virus e Genes

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Abstract
The segregation of resistant and susceptible phenotypes in response to infection by RSV(RAV 2) [Rous sarcoma virus (Rous associated virus)], RVS(RAV 50) and RSV(RAV 0), of avian RNA tumor virus subgroups B, D and E, respectively, was analyzed in several test crosses using chickens from the RPRL line 7-2, HPRS synthetic line E and the Rease-heath line C. The results were consistent with the view reported previously that the genes at the tve and tvb loci segregate independently and recombine under the Mendelian 2nd law of independent assortment. The dominant susceptibility es gene is expressed phenotypically when associated with the dominant susceptibility b8 gene, but its expression is suppressed when associated with 2 doses of the recessive resistance br gene. Genetic causes such as lack of penetration, recessive epistasis and/or complementary interaction between tvb and tve genes were discussed to account for the modified phenotypic expression of brbreses cells, i.e., resistance to subgroup E virus. As reported previously, the tvb genes control the cellular response to subgroup D virus.