FDG PET of Primary Benign and Malignant Bone Tumors: Standardized Uptake Value in 52 Lesions

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Abstract
PURPOSE: To evaluate the standardized uptake value (SUV) of 2-[fluorine-18]fluoro-2-deoxy-d-glucose (FDG) at positron emission tomography (PET) in the differentiation of benign from malignant bone lesions. MATERIALS AND METHODS: Fifty-two (19 malignant, 33 benign) primary bone lesions were examined with FDG PET prior to tissue diagnosis. The SUVs were calculated and compared between benign and malignant lesions and among histologic subgroups that included more than four cases. RESULTS: There was a statistically significant difference in SUV between benign (2.18 ± 1.52 [SD]) and malignant (4.34 ± 3.19) lesions in total (P = .002). However, giant cell tumors (n = 5; SUV, 4.64 ± 1.05) showed significantly higher SUV than chondrosarcomas (n = 7; SUV, 2.23 ± 0.74) (P = .036, adjusted for multiple comparisons) and had no statistically significant difference in SUV compared with osteosarcomas (n = 6; SUV, 3.07 ± 0.96) (P = .171). There was no statistically significant difference in SUV between fibrous dysplasias...