Effect of H Ion Concentration on Eluting Poliomyelitis Virus from Cotton Fiber
- 1 October 1945
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 60 (1) , 104-106
- https://doi.org/10.3181/00379727-60-15105
Abstract
A method for eluting poliomyelitis virus from cotton swabs suspended in a medium at pH values ranging from 4 to 8.1 is described. The Lansing strain of poliomyelitis virus was eluted from cotton fiber best at pH 8 using 1:100 and 1:500 dilution of virus. The mortality rate in mice increased with increasing acidity of the mouse brain-virus suspensions. Elution of virus is optimal at an alkaline pH. To obtain opt. mortality rates the eluate should be made acid before it is inoculated into mice.Keywords
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