Successful Culture of Rat Embryos on Human Serum: Use in the Detection of Teratogens
- 28 March 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 207 (4438) , 1471-1473
- https://doi.org/10.1126/science.7361097
Abstract
Growth of head-fold-stage rat embryos cultured with human serum for 48 hours was enhanced by supplementation with glucose. Embryo growth (protein and DNA contents) varied with the source of the serum. Serum from 16 of 19 untreated subjects produced normal embryos. Serum from five subjects undergoing cancer chemotherapy and six subjects receiving anticonvulsants was either lethal or teratogenic.Keywords
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