Overuse of acid suppressant drugs in patients with chronic renal failure.

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Abstract
Background. Patients with chronic renal failure (CRF) have a high prevalence of gastrointestinal symptoms. The use of acid suppressive therapy (AST) in these patients is unexplored. We assessed the use of and indication for AST in CRF patients and compared them with hospitalized patients and patients with another chronic disease. Methods. A total of 293 patients with CRF were compared with 261 hospitalized patients and 181 patients with another chronic disease. Information about AST, endoscopic investigations and indication for therapy were obtained by medical records and patient interviews. Results. The use of AST was higher in CRF patients (41%, PPConclusion. The majority of CRF patients had an inadequate indication for AST. Endoscopy seemed to be underused in these patients. PPIs were the dominating acid suppressive drug.

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