Statistical mechanics of noncovalent bonds in polyamino acids. VI. A simple model for side‐chain hydrogen bonds between helices
- 1 April 1965
- journal article
- research article
- Published by Wiley in Biopolymers
- Vol. 3 (4) , 357-367
- https://doi.org/10.1002/bip.1965.360030402
Abstract
The partition function of paper II for short polypetide chains is incorporated here into one for a simple model for side‐chain hydrogen bonds between helices. It is thus possible to calculate the fraction of amide hydrogen bonds, the fraction of side‐chain hydrogen bonds, and the number of bound protons as a function of temperature and pH. Illustrative data are presented for the probabilities of occurrence of intermediate structures and for the influence of the overall conformation on the observed pK's of ionizable groups.Keywords
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