Elevation of -Aminobutyric Acid in Rat Brain with Hydroxylamine.
- 1 August 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 101 (4) , 811-815
- https://doi.org/10.3181/00379727-101-25105
Abstract
The intraperitoneal injection of hydroxylamine (4.8 to 7.2 mg/kg body weight resulted in elevation of levels of gamma-aminobutyric acid in 8 cerebral areas of the rat. These elevated levels of gamma-aminobutyric acid were attained even after rats were pretreated with methylene blue to reduce the effects of methemoglobin formation. The effect of a single injection of hydroxylamine persisted for more than 5 hours. The potential value of this procedure for physiological study is discussed. The quantitative assay for gamma-aminobutyric acid was performed using an enzymatic technique.Keywords
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