Effect of Digitoxin On Creatinine and Histamine Output of the Isolated Heart.
- 1 February 1948
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 67 (2) , 144-147
- https://doi.org/10.3181/00379727-67-16229
Abstract
The perfusion fluid from isolated hearts of cats, rabbits, and rats contains creatinine and histamine. There is a sp. variation in the excretion of these substances. When digitoxin (1:-40,000) is added to the perfusion fluid, the creatinine output of the heart is not significantly altered in the 3 spp. studied. However, the histamine output of the cat and the rabbit heart decreases, while that of the rat heart remains unchanged. The isolated rat heart is much more resistant toward digitoxin than the cat and rabbit hearts.Keywords
This publication has 3 references indexed in Scilit:
- Blood histamine and cardiac activityThe Journal of Physiology, 1938
- Liberation of histamine by the heart muscleThe Journal of Physiology, 1936
- The pharmacological estimation of adenosine and histamine in bloodThe Journal of Physiology, 1935