Distribution of Intravenously Administered Ferrioxamine-59 and Ferric N, N'-Ethylenebis (a Imino-2-Hydroxy-5-Chlorophenylacetate) in Rats

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Abstract
The metabolism of ferric N,N[image]-ethylenebis ([alpha]-imino-2-hydroxy-5-chlorophenylacetate) (Fe Cl-EDDHA) and ferrioxamine B for the period up to 30 min. after i.v. [intravenous] injection into rats is singularly dependent upon their molecular architecture. Ferrioxamine, a relatively polar chelate, is not accumulated by any organs and is excreted in the urine. Fe Cl-EDDHA, a relatively non-polar chelate, is concentrated and excreted by both kidney and liver. These results point to the importance of ligand structure on the metabolism of Fe.