Asymmetric reduction of ketoxime O-alkyl ethers with sodium borohydride–Lewis acid
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 8,p. 1548-1549
- https://doi.org/10.1039/p19890001548
Abstract
Novel hydride agents formed by combining Lewis acids with sodium borohydride (NaBH4) reduce quantitatively ketoxime O-alkyl ethers to the corresponding optically active primary amines with high enantioselectivities (up to 95% e.e.) in the presence of chiral amino alcohols.Keywords
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