The urinary excretion of frusemide and its metabolites by kidney transplant patients
- 1 January 1987
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 32 (3) , 313-315
- https://doi.org/10.1007/bf00607581
Abstract
Summary Urine from 5 renal transplant recipients treated with frusemide was analyzed for unchanged frusemide (F), glucuronidated frusemide (G) and 4-chloro-5-sulfamoylanthranilic acid (CSA) by HPLC. In 3 recipients, whose renal function recovered steadily and whose hepatic function was normal throughout, the ratio of frusemide to its metabolites, F/(F+G+CSA), increased steadily in conjunction with the recovery of renal function. In one patient, who received frusemide 200–400 mg/day i.v., the urinary CSA concentration was 64–102 µg·ml−1. In 2 patients who experienced shock and/or hepatic dysfunction after transplantation, the F/(F+G+CSA) ratio fluctuated.Keywords
This publication has 4 references indexed in Scilit:
- Furosemide assays and disposition in healthy volunteers and renal transplant patients.1983
- Biotransformation of furosemide in kidney transplant patientsEuropean Journal of Clinical Pharmacology, 1983
- The Use of HPLC to Elucidate the Metabolism and Urinary Excretion of Furosemide and its Metabolic ProductsActa Pharmacologica et Toxicologica, 1981
- ABSORPTION AND DISPOSITION OF FUROSEMIDE IN HEALTHY-VOLUNTEERS, MEASURED WITH A METABOLITE-SPECIFIC ASSAY1980