Abnormal Red-Cell Calcium Pump in Patients with Idiopathic Hypercalciuria

Abstract
Idiopathic hypercalciuria is a common disorder whose inheritance suggests an enzyme abnormality in calcium transport. We measured calcium–magnesium–ATPase activity in erythrocytes from 38 patients (mean age [±SEM], 40±2.1 years) with idiopathic hypercalciuria (24-hour urinary calcium excretion ≥0.1 mmol per kilogram of body weight) and a history of multiple calcium oxalate kidney stones.