Biomimetic Membrane TransportviaDesigned Macrocyclic Host Molecules

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Abstract
Biomimetic approaches to naturally occurring ion transport were discussed. Selective transport systems of alkali, alkaline earth, heavy, and transition metal cations as well as organic cations and anions were successfully constructed by using “synthetic” ionophores. They were designed by considering (i) sizes of their molecular cavities for guest-binding; (ii) natures of their binding sites; and (iii) their three-dimensional ligand topologies. Their synthetic strategies, guest-binding and transport abilities, and biological significance were mainly described.