Improved Syntheses of Vinyl Imidazoles1
- 1 December 1986
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 16 (14) , 1761-1770
- https://doi.org/10.1080/00397918608057198
Abstract
A series of vinylimidazoles were synthesized via Wittig reactions on N-tritylimidazole-4-carboxaldehyde. Activated phosphonate ylids afforded yields in excess of 90% while the yields from unactivated ylids ranged from 10–82%. The trityl group may be removed by mild acid hydrolysis in high yield.Keywords
This publication has 12 references indexed in Scilit:
- Synthesis of 4,5-disubstituted imidazolesCanadian Journal of Chemistry, 1982
- Conformational and neighboring effects in graft polymerization of acrolein onto imidazole‐containing polymerJournal of Polymer Science: Polymer Chemistry Edition, 1982
- Convenient Synthesis of Alkyl Esters of Urocanic AcidJournal of Pharmaceutical Sciences, 1981
- Preparation and stereochemistry of 4-aryl-3-butenylamines. A novel synthesis of an oxazolo[2,3-a]isoindoleThe Journal of Organic Chemistry, 1980
- Polymer effect in graft polymerizations of acrolein onto imidazole‐containing polymerJournal of Polymer Science: Polymer Chemistry Edition, 1980
- The Wittig-Horner Reaction in Solid-Liquid Two Phase SystemsSynthesis, 1979
- Synthesis and antitumor properties of some isoindolylalkylphosphonium saltsJournal of Medicinal Chemistry, 1978
- Attempted inhibition of histidine decarboxylase with .beta.-alkyl analogs of histidineJournal of Medicinal Chemistry, 1977
- Ester des 4-Hydroxymethyl-imidazols und der 4-Imidazolessigsäure 2. Mitt. über Struktur-Wirkungs-Beziehungen bei HistaminanalogaArchiv der Pharmazie, 1974
- 2-(4-Imidazolyl)cyclopropylamineJournal of Medicinal Chemistry, 1970