A Practical and Robust Process to Produce SB-214857, Lotrafiban, ((2S)-7-(4,4^‘-Bipiperidinylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1, 4-Benzodiazepine-2-acetic Acid) Utilising an Enzymic Resolution as the Final Step

This publication has 6 references indexed in Scilit:

• A new synthesis of the GPIIb/IIIa receptor antagonist SB-214857-A
  Tetrahedron Letters, 2001
• An Alternative Synthesis of a Potent GPIIb/IIIa Receptor Antagonist
  Synlett, 1999
• A New and Convergent Synthesis of (2S)-7-(4,4‘-Bipiperidinylcarbonyl)-2,3,4,5- tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic Acid Using a Palladium-Catalysed Aminocarbonylation Reaction
  Organic Process Research & Development, 1998
• One Biocatalyst–Many Applications: The Use of Candida Antarctica B-Lipase in Organic Synthesis
  Biocatalysis and Biotransformation, 1998
• An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate
  Tetrahedron Letters, 1997
• Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists
  Journal of Medicinal Chemistry, 1996