Cyclosporine A in a case of refractory severe aplastic anaemia

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Abstract
A [7 yr old] boy developed severe aplastic anemia. Treatment with oxymetholone plus corticosteroids and later bolus methylprednisolone was ineffective. Following a 5 d [day] course with antithymocyte globulin, a partial remission was achieved, but thrombocytopenia necessitating platelet transfusions every 10-14 d persisted. Under treatment with cyclosporine A the thrombocytopenia improved markedly, and there is no need for further transfusion. These observations combined with those reported in another case of aplastic anemia indicate that cyclosporine A may be of value in some cases of aplastic anemia.

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