Specificity of Sodium-Dependent Electrogenic Sugar Transport in Amphibian Kidney Proximal Tubule

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Abstract
Microelectrode studies were performed to examine the specificity of the electrogenic sugar transport by Triturus proximal tubule. Two types of carriers could be distinguished, one having an affinity for D-mannose but not for D-xylose (M type), and the other having the reverse characteristics (X type). D-Glucose and alpha-methyl-D-glucoside had a relatively high affinity for both types of carriers, but D-galactose, D-fructose, 3-O-methyl-D-glucose, D-mannitol and L-glucose had no affinity for them. The observed structural requirements of renal sugar transport were different from and stricter than those of intestinal sugar transport observed in the same animal.

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