Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs

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Abstract
A new class of drugs that selectively block serotonin M-receptors on peripheral neurons was described. Because of their high affinity, some of these drugs are the most potent of any pharmacological class yet reported. They have allowed the identification of 3 M-receptor subtypes, 1 of which is responsible for mediating the painful effects of serotonin in humans. [Rats, rabbits and guinea pigs were used in this study.].