Phagocytic Activity of Leaves of Epimedium Species on Mouse Reticuloendotherial System
Open Access
- 1 January 1990
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 110 (3) , 179-185
- https://doi.org/10.1248/yakushi1947.110.3_179
Abstract
Effects of a 70% methanolic extract (E-S) from the dried leaves of Epimedium sagittatum on a phagocytic activity of reticuloendothelial system were studied by the carbon clearance method in mice. The clearance-rate of carbon significantly increased 1 h after the oral administration of E-S (200 or 500 mg/kg, one time/d for 5d). E-S activated the phagocytosis of carbon by Kupffer cells in the liver. Icariin and epimedin C isolated from E-S also activated the phagocytosis. These results suggest that E-S promotes the phagocytic activity of the reticuloendothelial system in mice and has a stimulatory effect on macrophage.Keywords
This publication has 1 reference indexed in Scilit:
- RETICULOENDOTHELIAL SYSTEM AND PASSIVE TRANSFER OF ENDOTOXIN TOLERANCEAnnals of the New York Academy of Sciences, 1960