The kinetics of skin thinning induced by topical fluticasone propionate 0·05% cream in volunteer subjects

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Abstract
Fluticasone propionate (FP) 0·05% (CutivateTM) cream is a novel corticosteroid used for the treatment of corticosteroid‐responsive dermatoses. To date there are no published data concerning its effect on cutaneous atrophy. This randomized, double‐blind study of 40 volunteer subjects was performed to investigate the kinetics of skin thinning induced by topical 0·05% FP cream vs. placebo after once‐daily application for 2–8 weeks. The results of this study showed no significant effect on the skin thickness of subjects after 8 weeks' treatment with 0·05% FP cream compared with placebo.