THIAMINE DEFICIENCY IN NORMAL RATS AND IN RATS MADE DIABETIC WITH ALLOXAN

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Abstract
Normal rats and rats made diabetic with alloxan were given a diet deficient in thiamine and were studied under paired-feeding conditions. The thiamine-deficient diet appeared to have a greater influence in altering appetite than in altering blood sugar levels, since the latter were very similar before polyneuritis became evident in both deficient and pair-fed animals. Near the termination of the expt. the deficient rats showed a tendency towards lower blood sugar levels and a greater wt. loss. This may have resulted from a decreased utilization of carbohydrate or decreased absorption of food from the intestines. The kidneys of thiamine-deficient rats were larger than those of their pair-mates and had larger Mal-pighian bodies. The urine vols., however, were larger in the pair-fed rats than in the deficient animals, particularly in the normal series. The primary cause of death in the deficient rats was probably not polyneuritis, per se, but inanition.

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