Effects of low-sodium solutions on the calcium-dependent slow action potentials in potassium-depolarized guinea-pig ventricular muscle.

Abstract
Lowering [Na]o [extracellular Na] down to 50% of the normal concentration only slightly reduced the overshoot of the Ca-dependent slow action potentials in K-depolarized guinea pig papillary muscles. The maximum rate of rise of the action potential also appeared to be independent of [Na]o. These results suggest that Na+ do not play a major role as charge carriers responsible for generation of the slow action potentials in this tissue.

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