Investigation of the dependence of human middle cerebral artery contractile activity on the presence of an atherosclerotic patch

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Abstract
In some cases, human middle cerebral artery segments reacted to vasoconstrictor stimuli, including noradrenalin, KCL, prostaglandin F2α, and activated platelets and neutrophils, by showing abnormally long-term contraction. All the segments were atherosclerotic, the atherosclerotic patch constricting the lumen to 30%–50%. Vasodilator concentrations that remove the ordinary contraction of vessels, only slightly limited the abnormal spastic reaction. A positive interaction between nifedipine and prostacyclin was revealed, and their combined use had a more marked anti-spasmatic effect than when these agents were used separately.