Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.
- 1 January 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (1) , 435-437
- https://doi.org/10.1073/pnas.76.1.435
Abstract
Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of 1st-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine and benzo[a]pyrene treatments; and no difference was found for X-ray treatment.This publication has 9 references indexed in Scilit:
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