Prenatal Screening for Down's Syndrome with Use of Maternal Serum Markers

27 August 1992

journal article
research article
Published by Massachusetts Medical Society in New England Journal of Medicine

Vol. 327 (9) , 588-593
https://doi.org/10.1056/nejm199208273270902

Abstract

Approximately 35 percent of all cases of Down's syndrome in fetuses can be detected by measuring maternal serum alpha-fetoprotein during the second trimester in the general population of pregnant women. Recent case–control studies indicate that this detection rate could be approximately doubled by measuring serum levels of unconjugated estriol and chorionic gonadotropin, which are abnormally low and abnormally high, respectively, in women carrying fetuses affected by Down's syndrome.

Keywords

This publication has 11 references indexed in Scilit:

Combining maternal serum α-fetoprotein measurements and age to screen for Down syndrome in pregnant women under age 35
American Journal of Obstetrics and Gynecology, 1989
Maternal serum screening for Down's syndrome in early pregnancy.
BMJ, 1988
Low second trimester maternal serum unconjugated oestriol in pregnancies with Down's syndrome
BJOG: An International Journal of Obstetrics and Gynaecology, 1988
Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities
Prenatal Diagnosis, 1987
8 Recent advances in screening for neural tube defects and Down's syndrome
Bailliere's Clinical Obstetrics and Gynaecology, 1987
Screening for Fetal Down's Syndrome in Pregnancy by Measuring Maternal Serum Alpha-Fetoprotein Levels
New England Journal of Medicine, 1987
Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha‐fetoprotein level
BJOG: An International Journal of Obstetrics and Gynaecology, 1987
The effect of estimating gestational age by ultrasound cephalometry on the sensitivity of alpha‐fetoprotein screening for Down's syndrome
BJOG: An International Journal of Obstetrics and Gynaecology, 1987
An association between low maternal serum α-fetoprotein and fetal chromosomal abnormalities
American Journal of Obstetrics and Gynecology, 1984
MATERNAL SERUM ALPHA-FETOPROTEIN MEASUREMENT: A SCREENING TEST FOR DOWN SYNDROME
The Lancet, 1984