Amphetaminanaloga des Ruthenocens als Radiodiagnostika: Gehirn-Affinität von Ruthenocenyl-isopropylamin
- 1 February 1986
- journal article
- Published by Georg Thieme Verlag KG in RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren
- Vol. 144 (02) , 227-229
- https://doi.org/10.1055/s-2008-1048776
Abstract
N-alkyl derivatives of 1-ruthenocenoyl-2-aminopropane (Rc-amphetamine) were labelled with 103Ru and their organ distributions were measured in mice and rats. All Rc-amphetamines showed a high affinity for brain and lung. A concentration ratio brain/blood up to 17:1 and lung/blood up to 80:1 was measured. The advantages of 97Ru labelled Rc-amphetamine compared to 123I labelled amphetamine for measurement of regional cerebral blood flow are discussed.Keywords
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