Serum Transferrin Saturation, Stroke Incidence, and Mortality in Women and Men: The NHANES I Epidemiologic Followup Study

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Abstract
Several studies have examined relatively large body iron stores and the risk of coronary heart disease with conflicting results. No reports of studies that associated body iron stores with stroke were found. To test the hypothesis that relatively high transferrin saturation is associated with increased stroke incidence and mortality in women and men, data from a follow-up study of a national cohort were examined. A total of 5, 033 women and men aged 45–74 years from the First National Health and Nutrition Examination Survey Epidemiologic Followup Study who were free of stroke at baseline were followed an average of 12 years. Transferrin saturation (serum iron concentration divided by total iron binding capacity) was used as a measure of the amount of circulating iron available to tissues. In white women aged 45–74, after adjusting for age or for age and other risk variables, the authors observed a significant U-shaped association of transferrin saturation with risk of incident stroke (>44% vs. 30–36%, relative risk = 1.96, 95% confidence interval 1.15–3.36; Am J Epidemiol 1996; 144: 59–68.

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