A very short degradation of the bile acid side chain
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 1383-1385
- https://doi.org/10.1039/c39870001383
Abstract
Reaction of the cholanic acid derivative (1) with thionyl chloride and pyridine gave, after quenching with methanol, the α-sulphine ester (3); treatment with acetic anhydride–sulphuric acid afforded the keto ester (5) which, on exposure to air in the presence of copper(II) ions and base, gave the 20-keto pregnane derivative (9) in excellent overall yield.Keywords
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