THE RELATIONSHIP OF DIETARY FACTORS TO RAT SERUM ALKALINE PHOSPHATASE

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Abstract
Increased levels of serum alkaline phosphatase were produced in growing rats by diets low in calcium or by the addition of sodium oxalate or rhubarb to diets containing adequate amounts of calcium. In addition, variations from normal in levels of serum phosphorus, calcium, and magnesium, as well as the ash of the tibiae, indicate that the animals were rachitic. The amount of calcium retained in the bodies of animals maintained on a diet containing rhubarb, which has a high oxalate content, were very much lower than in growing rats fed a normal calcium diet.