Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Top Cited Papers
Open Access
- 8 March 2013
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 339 (6124) , 1216-1219
- https://doi.org/10.1126/science.1231097
Abstract
It's a SIRT: Intense attention has focused on the SIRT1 deacetylase as a possible target for anti-aging drugs. But unexpected complications in assays of SIRT1 activity have made it unclear whether compounds thought to be sirtuin-activating compounds (STACs) are really direct regulators of the enzyme. Further exploration of these effects by Hubbard et al. (p. 1216 ; see the Perspective by Yuan and Marmorstein ) revealed that interaction of SIRT1 with certain substrates allows activation of SIRT1 by STACs and identified critical amino acids in SIRT1 required for these effects. Mouse myoblasts reconstituted with SIRT1 mutated at this amino acid lost their responsiveness to STACs.Keywords
This publication has 30 references indexed in Scilit:
- SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial FunctionCell Metabolism, 2012
- SIRT1 associates with eIF2-alpha and regulates the cellular stress responseScientific Reports, 2011
- Peptide Switch Is Essential for Sirt1 Deacetylase ActivityMolecular Cell, 2011
- SRT1720 improves survival and healthspan of obese miceScientific Reports, 2011
- A continuous microplate assay for sirtuins and nicotinamide-producing enzymesAnalytical Biochemistry, 2009
- CBP/p300-mediated acetylation of histone H3 on lysine 56Nature, 2009
- Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetesNature, 2007
- Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1αThe EMBO Journal, 2007
- Resveratrol improves health and survival of mice on a high-calorie dietNature, 2006
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature, 2003