POLYOSTOTIC FIBROUS DYSPLASIA IN ONE OF NEGRO TWIN GIRLS

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Abstract
A patient displaying all the features of the so-called "Albright syndrome" was studied over a period of 20 months. Diagnostic findings were polyostotic fibrous dysplasia, skin pigmentation, sexual and somatic precocity and normal serum Ca and inorganic P levels with consistent elevation of serum phosphatase. This case was unusual in that the patient was a Negro and that she had a normal dizygotic twin. Comparative study of these twins suggested a germ plasm defect as the primary etiological factor. No causal influence could be ascribed to heredity, environment or infection. Continued observation of these twins may contribute to our understanding of this bizarre condition.

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