Drugs derived from cannabinoids. 7. Tachycardia and analgesia structure-activity relationships in .DELTA.9-tetrahydrocannabinol and some synthetic analogs
- 1 August 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (8) , 809-811
- https://doi.org/10.1021/jm00206a018
Abstract
.DELTA.9-Tetrahydrocannabinol (.DELTA.9-THC) and 8 other synthetic analogs induced a dose-related increase in heart rate in the conscious Wistar rat. In a comparison of tachycardia with analgesic activity (mouse hot-plate and antiwrithing tests), the water-soluble ester derivatives of 1-hydroxy-3-(3-methyl-2-octyl)-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyran, had the least potency for tachycardia and the greatest potency for analgesia. These compounds may have promise as therapeutic agents.Keywords
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