Effects of triethyl tin on pain reactivity and neuromotor function of rats

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Abstract
Male Fischer-344 rats were given 14 doses of triethyl tin (TET) s.c. for 3 wk. Responsiveness to painful stimulation and muscular strength were measured at the end of dosing and after 2 wk of recovery. Responsiveness to painful stimuli was elevated by TET in tests requiring a relatively large motor response (tail flick, hot plate) and was associated with concurrent decreases in hindlimb grip strength. Reactivity, as measured by an operant titration procedure requiring a nose poke response, was not affected by TET. All neurotoxic effects of TET were reversible by 2 wk after cessation of dosing. TET did not affect reactivity to pain when TET-induced neuromotor deficits were taken into account.