Durations of Action of d-Tubocurarine and Gallamine

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Abstract
The durations of action in man of 5 different single doses of d-tubocurarine and 3 different single doses of gallamine were studied. Duration was estimated by observing the response of the adductor muscles of the thumb to supramaximal ulnar nerve stimulation. Ten per cent recovery time from d-tubocurarine was dose-dependent, averaging from 10 to 71 min. in a dose range from 4 to 16 mg/m2 body surface area (7-28 mg). Gallamine was studied in both normally-ventilated and hyperventilated patients. In the former, 10% recovery averaged from 2.9 min to 40 min in a dose range from approximately 18 to 72 mg/m2 body surface area (30-130 mg). In the latter, 10% recovery averaged from 6.4 to 64 min in a similar dose range. The difference in the durations of action of the 2 gallamine groups was statistically significant (P<0.001). At equal twitch-suppression doses, recovery from d-tubocurarine took 1.5 times longer than recovery from gallamine.

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