Spinal antinociception

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Abstract
In this review some non-opioid spinally located transmitter systems, that may be exploited for clinical pain treatment, are discussed. a2-Agonists, adenosine analogues, inhibitors of nitric oxide synthesis, N-methyl-D-aspartate (NMDA)-antagonists, and somatostatin agonism all produce receptor-selective antinociceptive effects. This may lead to rational advances in pain management.

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