Amiodarone in Patients on Long-Term Dialysis

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Abstract
To the Editor: The antiarrhythmic drug amiodarone has received increasing attention over the past few years because of its proved efficacy in resistant forms of ventricular and supraventricular tachyarrhythmias.1 , 2 The pharmacokinetic and metabolic profile of amiodarone is gradually emerging from animal3 and human studies,4 5 6 7 which have documented the existence of at least one metabolite, the N-dealkyl derivative, with general kinetic behavior similar to that of the parent compound and minimal urinary excretion of unchanged amiodarone. We describe here the time course of amiodarone and its metabolite in patients with chronic renal insufficiency who were maintained on hemodialysis.Five . . .

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